GAG replenisher

Sodium Hyaluronate

What is Solatum GAG replenisher?

Solatum GAG replenisher relieves symptoms associated with chronic cystitis, such as pain, frequency and urgency. Your doctor may suggest Solatum GAG replenisher if you have chronic cystitis, including:
Solatum GAG replenisher is a single-use, pre-filled syringe containing a solution of highly purified non-animal Sodium Hyaluronate – also known as salt of hyaluronic acid (HA) or hyaluronate.

How does Solatum GAG replenisher work?

Solatum GAG replenisher contains hyaluronic acid (HA). Hyaluronic acid is a type of glycosaminoglycan (GAG) that’s naturally found in the GAG layer. The GAG layer is part of the mucus lining of the bladder that provides a protective barrier and primary defence mechanism against microorganisms and irritants found in the urine. Damage to this GAG layer can destroy the protective function of the lining, meaning urine can irritate the bladder and surrounding muscles and nerves. There’s strong evidence that a deficiency in the GAG layer is linked to many chronic inflammatory bladder diseases, including recurrent urinary tract infections (UTIs), chemical or radiation cystitis, and painful bladder syndrome/interstitial cystitis. It’s thought that replenishing the GAG layer can restore it’s protective function to treat and prevent these conditions. Instilling HA into the bladder can help rebuild the GAG layer and restore its protective function of providing a barrier against bacteria and irritants.

Normal functional bladder

Damage to GAG layer

Bladder with GAG Replenisher

What will happen at my appointment?

Your doctor or nurse will instil the solution from the syringe into your bladder using a small catheter. You will then need to hold the solution in your bladder for as long as possible – ideally for up to 60 minutes and for at least 30 minutes. This can be performed at an out-patient appointment. The recommended dosage is once a week for four to six weeks, and then monthly until your symptoms resolve – usually six months in total. However, your doctor will advise what is the best dosage regimen for your specific needs.


Solatum GAG replenisher is not suitable for patients with known hypersensitivity reactions. As there is no clinical evidence available on the use of HA in children, pregnant and lactating women, Solatum GAG replenisher is not recommended for use in these patients. Discontinue use if adverse reactions are experienced and speak to your doctor if you experience any side effects. Adverse events can be reported here.


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