Indications and mode of action of hyaluronic acid (HA)

Indications and mode of action of HA lubrication and buffering of damaged cartilage.1 HA has been shown to:
  • Suppress inflammation
  • Stimulation of production of high molecular HA sodium which can help with joint pain
  • Increase mobility
  • Decrease synovitis
  • Delay disease progression (of osteoarthritis)

Efficacy of HA in the management of osteoarthritis

Hyaluronic acid is a potential bright spot for helping lower the side effects (of osteoarthritis). Its effectiveness is due to the many methods of actions it deploys, including lubrication, anti-inflammatory and chondroprotective effects. 2

A retrospective longitudinal study involving knee osteoarthritis patients using medico-administrative databases in France demonstrated the effectiveness of hyaluronic acid injections in delaying total knee replacement (TKR) from +51 to +217 days at 1 and 7.5 years, respectively.3

A retrospective longitudinal study involving knee osteoarthritis patients3

Kaplan-Meier curves of time without TKR for HA and non-HA groups.

HA group: patients who received at least one IA HA injection during their follow-up period, non-HA group: patients who received only CS as IA injections, TKR: total knee replacement, IA: intra-articular, HA: hyaluronic acid, CS: corticosteroids.


  1. Solatum Intra-articular Joint Injection Sodium Hyaluronate IFU 2019.
  2. Bowman et al. 2018.
  3. Delbarre et al. 2017

© Solatumfarma 2019